A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome

Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in the fate-specification step has been reported, the mechanisms and key regulators underlying the accelerated proliferation of astrocyte precursor cells (APCs) in DS remai...

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Udgivet i:Commun Biol
Main Authors: Kawatani, Keiji, Nambara, Toshihiko, Nawa, Nobutoshi, Yoshimatsu, Hidetaka, Kusakabe, Haruna, Hirata, Katsuya, Tanave, Akira, Sumiyama, Kenta, Banno, Kimihiko, Taniguchi, Hidetoshi, Arahori, Hitomi, Ozono, Keiichi, Kitabatake, Yasuji
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203796/
https://ncbi.nlm.nih.gov/pubmed/34127780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02242-7
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