Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line

A spontaneously reverted iPSC line was identified from an A-T subject with heterozygous ATM truncation mutations. The reverted iPSC line expressed ATM protein and was capable of radiation-induced phosphorylation of CHK2 and H2A.X. Genome-wide SNP analysis confirmed a match to source T cells and also...

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Pubblicato in:Stem Cell Reports
Autori principali: Lin, Lucy, Swerdel, Mavis R., Lazaropoulos, Michael P., Hoffman, Gary S., Toro-Ramos, Alana J., Wright, Jennifer, Lederman, Howard, Chen, Jianmin, Moore, Jennifer C., Hart, Ronald P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682125/
https://ncbi.nlm.nih.gov/pubmed/26677768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.10.010
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