Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele

Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increased risk of addiction-associated phenotypes in humans yet little is known the underlying neural basis. Induced pluripotent stem cells (iPSCs) were derived from donors homozygous for either the major (D398) or the...

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Publicado no:Sci Rep
Main Authors: Oni, Eileen N., Halikere, Apoorva, Li, Guohui, Toro-Ramos, Alana J., Swerdel, Mavis R., Verpeut, Jessica L., Moore, Jennifer C., Bello, Nicholas T., Bierut, Laura J., Goate, Alison, Tischfield, Jay A., Pang, Zhiping P., Hart, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048107/
https://ncbi.nlm.nih.gov/pubmed/27698409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34341
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