Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts

Chromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects on organismal growth and development, regardless of the karyotype, suggesting that...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Nawa, Nobutoshi, Hirata, Katsuya, Kawatani, Keiji, Nambara, Toshihiko, Omori, Sayaka, Banno, Kimihiko, Kokubu, Chikara, Takeda, Junji, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Okuzaki, Daisuke, Taniguchi, Hidetoshi, Arahori, Hitomi, Wada, Kazuko, Kitabatake, Yasuji, Ozono, Keiichi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663065/
https://ncbi.nlm.nih.gov/pubmed/31356639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219592
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