Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts

Chromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects on organismal growth and development, regardless of the karyotype, suggesting that...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nawa, Nobutoshi, Hirata, Katsuya, Kawatani, Keiji, Nambara, Toshihiko, Omori, Sayaka, Banno, Kimihiko, Kokubu, Chikara, Takeda, Junji, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Okuzaki, Daisuke, Taniguchi, Hidetoshi, Arahori, Hitomi, Wada, Kazuko, Kitabatake, Yasuji, Ozono, Keiichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663065/
https://ncbi.nlm.nih.gov/pubmed/31356639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219592
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