Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts

Chromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects on organismal growth and development, regardless of the karyotype, suggesting that...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Nawa, Nobutoshi, Hirata, Katsuya, Kawatani, Keiji, Nambara, Toshihiko, Omori, Sayaka, Banno, Kimihiko, Kokubu, Chikara, Takeda, Junji, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Okuzaki, Daisuke, Taniguchi, Hidetoshi, Arahori, Hitomi, Wada, Kazuko, Kitabatake, Yasuji, Ozono, Keiichi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663065/
https://ncbi.nlm.nih.gov/pubmed/31356639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219592
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