Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis

Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus, is a neglected tropical disease mostly affecting sub-Saharan Africa and is responsible for >1.3 million years lived with disability. Current control relies almost entirely on ivermectin, which suppresses symptoms c...

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Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Bah, Germanus S., Schneckener, Sebastian, Hahnel, Steffen R., Bayang, Nicolas H., Fieseler, Helena, Schmuck, Gabriele M., Krebber, Ralph, Sarr, Anouk, Terjung, Carsten, Ngangyung, Henrietta F., Ekale, David D., Mfopit, Youssouf M., Rufener, Lucien, Graham-Brown, John, Tanya, Vincent N., Glenschek-Sieberth, Martin, Kulke, Daniel, Makepeace, Benjamin L.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202924/
https://ncbi.nlm.nih.gov/pubmed/34077488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009601
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