Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity

We recently documented that gain-of-function (GOF) mutant p53 (mtp53) R273H in triple negative breast cancer (TNBC) cells interacts with replicating DNA and PARP1. The missense R273H GOF mtp53 has a mutated central DNA binding domain that renders it unable to bind specifically to DNA, but maintains...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ellison, Viola, Annor, George K., Freedman, Clara, Xiao, Gu, Lundine, Devon, Freulich, Elzbieta, Prives, Carol, Bargonetti, Jill
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2021
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202772/
https://ncbi.nlm.nih.gov/pubmed/34136083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27975
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