Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer

Over 80% of Triple Negative Breast Cancers (TNBC) express mutant p53 (mtp53) and some contain oncogenic gain-of-function (GOF) p53. We previously reported that GOF mtp53 R273H upregulates the chromatin association of Mini Chromosome Maintenance (MCM) proteins MCM2–7 and Poly-ADP-Ribose Polymerase (P...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Xiao, Gu, Lundine, Devon, Annor, George K., Canar, Jorge, Ellison, Viola, Polotskaia, Alla, Donabedian, Patrick L., Reiner, Thomas, Khramtsova, Galina F., Olopade, Olufunmilayo I., Mazo, Alexander, Bargonetti, Jill
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002183/
https://ncbi.nlm.nih.gov/pubmed/31776133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1036
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