Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer

Activation of mitogen-activated protein kinases (MAPKs) is a key factor in the pathogenesis of cancer, although the specific role of mitogen-activated protein kinase kinase (MEK1) is not well understood. Villin promoter-driven Cre expression was used to excise a floxed stop cassette from a phosphomi...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Shneider, Benjamin L., Cortes-Santiago, Nahir, Schady, Deborah A., Krishnamoorthy, Swapna, Thevananther, Sundararajah, Rajapakshe, Kimal, Perera, Dimuthu, Huang, Shixia, Coarfa, Cristian
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202241/
https://ncbi.nlm.nih.gov/pubmed/33470189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00065.2020
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