SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stress

Ataxia telangiectasia and Rad3 related (ATR) activation after replication stress involves a cascade of reactions, including replication protein A (RPA) complex loading onto single-stranded DNA and ATR activator loading onto chromatin. The contribution of histone modifications to ATR activation, howe...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhu, Qian, Yang, Qiaoyan, Lu, Xiaopeng, Wang, Hui, Tong, Lili, Li, Zheng, Liu, Ge, Bao, Yantao, Xu, Xingzhi, Gu, Luo, Yuan, Jian, Liu, Xiangyu, Zhu, Wei-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201831/
https://ncbi.nlm.nih.gov/pubmed/34074749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011278118
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