Neural basis of opioid-induced respiratory depression and its rescue

Opioid-induced respiratory depression (OIRD) causes death following an opioid overdose, yet the neurobiological mechanisms of this process are not well understood. Here, we show that neurons within the lateral parabrachial nucleus that express the µ-opioid receptor (PBL(Oprm1) neurons) are involved...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Liu, Shijia, Kim, Dong-Il, Oh, Tae Gyu, Pao, Gerald M., Kim, Jong-Hyun, Palmiter, Richard D., Banghart, Matthew R., Lee, Kuo-Fen, Evans, Ronald M., Han, Sung
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2021
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201770/
https://ncbi.nlm.nih.gov/pubmed/34074761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022134118
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