Neural basis of opioid-induced respiratory depression and its rescue

Opioid-induced respiratory depression (OIRD) causes death following an opioid overdose, yet the neurobiological mechanisms of this process are not well understood. Here, we show that neurons within the lateral parabrachial nucleus that express the µ-opioid receptor (PBL(Oprm1) neurons) are involved...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Shijia, Kim, Dong-Il, Oh, Tae Gyu, Pao, Gerald M., Kim, Jong-Hyun, Palmiter, Richard D., Banghart, Matthew R., Lee, Kuo-Fen, Evans, Ronald M., Han, Sung
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201770/
https://ncbi.nlm.nih.gov/pubmed/34074761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022134118
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