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Neural basis of opioid-induced respiratory depression and its rescue

Opioid-induced respiratory depression (OIRD) causes death following an opioid overdose, yet the neurobiological mechanisms of this process are not well understood. Here, we show that neurons within the lateral parabrachial nucleus that express the µ-opioid receptor (PBL(Oprm1) neurons) are involved...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Liu, Shijia, Kim, Dong-Il, Oh, Tae Gyu, Pao, Gerald M., Kim, Jong-Hyun, Palmiter, Richard D., Banghart, Matthew R., Lee, Kuo-Fen, Evans, Ronald M., Han, Sung
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201770/
https://ncbi.nlm.nih.gov/pubmed/34074761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022134118
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