The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity

In nonalcoholic steatohepatitis animal models, an increased lipid droplet size in hepatocytes is associated with fibrogenesis. Hepatocytes with large droplet (Ld-MaS) or small droplet (Sd-MaS) macrovesicular steatosis may coexist in the human liver, but the factors associated with the predominance o...

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Publicat a:Int J Mol Sci
Autors principals: Ferri, Flaminia, Carotti, Simone, Carpino, Guido, Mischitelli, Monica, Cantafora, Alfredo, Molinaro, Antonio, Argenziano, Maria Eva, Parisse, Simona, Corsi, Alessandro, Riminucci, Mara, Lai, Quirino, Mennini, Gianluca, Spadetta, Gustavo, Pugliese, Francesco, Rossi, Massimo, Morini, Sergio, Gaudio, Eugenio, Ginanni Corradini, Stefano
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8200978/
https://ncbi.nlm.nih.gov/pubmed/34198853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22116100
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