Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients

The FcγRIIA/CD32A is mainly expressed on platelets, myeloid and several endothelial cells. Its affinity is considered insufficient for allowing significant binding of monomeric IgG, while its H131R polymorphism (histidine > arginine at position 131) influences affinity for multimeric IgG2. Platel...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Thibault, Gilles, Paintaud, Gilles, Sung, Hsueh Cheng, Lajoie, Laurie, Louis, Edouard, Desvignes, Celine, Watier, Hervé, Gouilleux-Gruart, Valérie, Ternant, David
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8199937/
https://ncbi.nlm.nih.gov/pubmed/34205175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22116051
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