Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients

AIMS: Rituximab is a monoclonal antibody directed against CD20, which is approved in rheumatoid arthritis (RA). This study aimed at assessing the influence of CD19+ cell counts as target‐antigen amount, and of immunoglobulin G (IgG) serum concentrations on rituximab pharmacokinetics in RA patients....

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Lioger, Bertrand, Edupuganti, Soujanya Ratna, Mulleman, Denis, Passot, Christophe, Desvignes, Céline, Bejan‐Angoulvant, Théodora, Thibault, Gilles, Gouilleux‐Gruart, Valérie, Mélet, Julien, Paintaud, Gilles, Ternant, David
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510084/
https://ncbi.nlm.nih.gov/pubmed/28230269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13270
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