NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition

Although histone deacetylase 8 (HDAC8) plays a role in glioblastoma multiforme (GBM), whether its inhibition facilitates the treatment of temozolomide (TMZ)-resistant GBM (GBM-R) remains unclear. By assessing the gene expression profiles from short hairpin RNA of HDAC8 in the new version of Connecti...

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Publicado no:Int J Mol Sci
Main Authors: Tsai, Cheng-Yu, Ko, Huey-Jiun, Chiou, Shean-Jaw, Lai, Yu-Ling, Hou, Chia-Chung, Javaria, Tehseen, Huang, Zi-Yi, Cheng, Tai-Shan, Hsu, Tsung-I, Chuang, Jian-Ying, Kwan, Aij-Lie, Chuang, Tsung-Hsien, Huang, Chi-Ying F., Loh, Joon-Khim, Hong, Yi-Ren
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8199487/
https://ncbi.nlm.nih.gov/pubmed/34072831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115907
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