A scoutRNA is required for some type V CRISPR-Cas systems

CRISPR-Cas12c/d proteins share limited homology with Cas12a and Cas9 bacterial CRISPR RNA (crRNA)-guided nucleases used widely for genome editing and DNA detection. However, Cas12c (C2c3)- and Cas12d (CasY)-catalyzed DNA cleavage and genome editing activities have not been directly observed. We show...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Harrington, Lucas B., Ma, Enbo, Chen, Janice S., Witte, Isaac P., Gertz, Dov, Paez-Espino, David, Al-Shayeb, Basem, Kyrpides, Nikos C., Burstein, David, Banfield, Jillian F., Doudna, Jennifer A.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8196889/
https://ncbi.nlm.nih.gov/pubmed/32645367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.022
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