Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

Target protection proteins confer resistance to the host organism by directly binding to the antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F-subtype (ARE-ABCFs), which are widely distributed throughout Gram-positive bacte...

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Publicat a:Nat Commun
Autors principals: Crowe-McAuliffe, Caillan, Murina, Victoriia, Turnbull, Kathryn Jane, Kasari, Marje, Mohamad, Merianne, Polte, Christine, Takada, Hiraku, Vaitkevicius, Karolis, Johansson, Jörgen, Ignatova, Zoya, Atkinson, Gemma C., O’Neill, Alex J., Hauryliuk, Vasili, Wilson, Daniel N.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8196190/
https://ncbi.nlm.nih.gov/pubmed/34117249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23753-1
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