KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

The epithelial-to-mesenchymal transition (EMT) is considered a transcriptional process that induces a switch in cells from a polarized state to a migratory phenotype. Here, we show that KSR1 and ERK promote EMT-like phenotype through the preferential translation of Epithelial-Stromal Interaction 1 (...

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Udgivet i:eLife
Main Authors: Rao, Chaitra, Frodyma, Danielle E, Southekal, Siddesh, Svoboda, Robert A, Black, Adrian R, Guda, Chittibabu, Mizutani, Tomohiro, Clevers, Hans, Johnson, Keith R, Fisher, Kurt W, Lewis, Robert E
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195604/
https://ncbi.nlm.nih.gov/pubmed/33970103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66608
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