Overcoming Kinetic and Thermodynamic Challenges of Classic Cope Rearrangements

Systematic evaluation of 1,5-dienes bearing 3,3-electron-withdrawing groups and 4-methylation results in the discovery of a Cope rearrangement for Meldrum’s acid-containing substrates that have unexpectedly favorable kinetic and thermodynamic profiles. The protocol is quite general due to a concise...

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Bibliographic Details
Published in:J Org Chem
Main Authors: Fereyduni, Ehsan, Lahtigui, Ouidad, Sanders, Jacob N., Tomiczek, Breanna M., Mannchen, Michael D., Yu, Roland A., Houk, K. N., Grenning, Alexander J.
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195263/
https://ncbi.nlm.nih.gov/pubmed/33476142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c02690
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