A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice

AIMS: To assess effects of DF402, a bioisostere of Dimebon/Latrepirdine, on the disease progression in the transgenic model of amyotrophic lateral sclerosis (ALS) caused by expression of pathogenic truncated form of human FUS protein. METHODS: Mice received DF402 from the age of 42 days and the onse...

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Pubblicato in:CNS Neurosci Ther
Autori principali: Chaprov, Kirill, Rezvykh, Alexander, Funikov, Sergei, Ivanova, Tamara A., Lysikova, Ekaterina A., Deykin, Alexei V., Kukharsky, Michail S., Yu. Aksinenko, Alexey, Bachurin, Sergey O., Ninkina, Natalia, Buchman, Vladimir L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193697/
https://ncbi.nlm.nih.gov/pubmed/33754495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13637
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