Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db/db mice

STUDY OBJECTIVES: Obesity leads to obstructive sleep apnea (OSA), which is recurrent upper airway obstruction during sleep, and obesity hypoventilation syndrome (OHS), hypoventilation during sleep resulting in daytime hypercapnia. Impaired leptin signaling in the brain was implicated in both conditi...

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Udgivet i:Sleep
Main Authors: Pho, Huy, Berger, Slava, Freire, Carla, Kim, Lenise J, Shin, Mi-Kyung, Streeter, Stone R, Hosamane, Nishitha, Cabassa, Meaghan E, Anokye-Danso, Frederick, Dergacheva, Olga, Amorim, Mateus R, Fleury-Curado, Thomaz, Jun, Jonathan C, Schwartz, Alan R, Ahima, Rexford S, Mendelowitz, David, Polotsky, Vsevolod Y
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Sleep Disordered Breathing
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193564/
https://ncbi.nlm.nih.gov/pubmed/33624805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsab046
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