Immunization with a heat-killed bacterium, Mycobacterium vaccae NCTC 11659, prevents the development of cortical hyperarousal and a PTSD-like sleep phenotype after sleep disruption and acute stress in mice

STUDY OBJECTIVES: Sleep deprivation induces systemic inflammation that may contribute to stress vulnerability and other pathologies. We tested the hypothesis that immunization with heat-killed Mycobacterium vaccae NCTC 11659 (MV), an environmental bacterium with immunoregulatory and anti-inflammator...

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Detalhes bibliográficos
Publicado no:Sleep
Main Authors: Bowers, Samuel J, Lambert, Sophie, He, Shannon, Lowry, Christopher A, Fleshner, Monika, Wright, Kenneth P, Turek, Fred W, Vitaterna, Martha H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic Science of Sleep and Circadian Rhythms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193553/
https://ncbi.nlm.nih.gov/pubmed/33283862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsaa271
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