Structure-based redesigning of pentoxifylline analogs against selective phosphodiesterases to modulate sperm functional competence for assisted reproductive technologies

Phosphodiesterase (PDE) inhibitors, such as pentoxifylline (PTX), are used as pharmacological agents to enhance sperm motility in assisted reproductive technology (ART), mainly to aid the selection of viable sperm in asthenozoospermic ejaculates and testicular spermatozoa, prior to intracytoplasmic...

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Udgivet i:Sci Rep
Main Authors: Satish, Mutyala, Kumari, Sandhya, Deeksha, Waghela, Abhishek, Suman, Nitin, Kulhar, Adiga, Satish Kumar, Hegde, Padmaraj, Dasappa, Jagadeesh Prasad, Kalthur, Guruprasad, Rajakumara, Eerappa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192908/
https://ncbi.nlm.nih.gov/pubmed/34112881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91636-y
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