Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors

Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d, 5e, 5f, 5g, 5h, and...

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Detalhes bibliográficos
Publicado no:Int J Med Chem
Main Authors: Kumbar, Mahadev N., Kamble, Ravindra R., Kamble, Atulkumar A., Salian, Sujith Raj, Kumari, Sandhya, Nair, Ramya, Kalthur, Guruprasad, Adiga, Satish Kumar, Prasad, D. Jagadeesh
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779523/
https://ncbi.nlm.nih.gov/pubmed/26998358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9890630
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