Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors

Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d, 5e, 5f, 5g, 5h, and...

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Veröffentlicht in:Int J Med Chem
Hauptverfasser: Kumbar, Mahadev N., Kamble, Ravindra R., Kamble, Atulkumar A., Salian, Sujith Raj, Kumari, Sandhya, Nair, Ramya, Kalthur, Guruprasad, Adiga, Satish Kumar, Prasad, D. Jagadeesh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779523/
https://ncbi.nlm.nih.gov/pubmed/26998358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9890630
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