Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells

The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty acid precursors (VLC-PUFA, n...

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Publicado no:Sci Rep
Main Authors: Calandria, Jorgelina M., Bhattacharjee, Surjyadipta, Maness, Nicholas J., Kautzmann, Marie-Audrey I., Asatryan, Aram, Gordon, William C., Do, Khanh V., Jun, Bokkyoo, Mukherjee, Pranab K., Petasis, Nicos A., Bazan, Nicolas G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192580/
https://ncbi.nlm.nih.gov/pubmed/34112906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91794-z
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