The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation

The Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is caused by mutations in LSH/HELLS, a chromatin remodeler promoting incorporation of histone variant macroH2A. Here, we demonstrate that LSH depletion results in degradation of nascent DNA at stalled replication forks an...

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Publicat a:Nat Commun
Autors principals: Xu, Xiaoping, Ni, Kai, He, Yafeng, Ren, Jianke, Sun, Chongkui, Liu, Yie, Aladjem, Mirit I., Burkett, Sandra, Finney, Richard, Ding, Xia, Sharan, Shyam K., Muegge, Kathrin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192551/
https://ncbi.nlm.nih.gov/pubmed/34112784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23809-2
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