Human heart-forming organoids recapitulate early heart and foregut development

Organoid models of early tissue development have been produced for the intestine, brain, kidney and other organs, but similar approaches for the heart have been lacking. Here we generate complex, highly structured, three-dimensional heart-forming organoids (HFOs) by embedding human pluripotent stem...

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Udgivet i:Nat Biotechnol
Main Authors: Drakhlis, Lika, Biswanath, Santoshi, Farr, Clara-Milena, Lupanow, Victoria, Teske, Jana, Ritzenhoff, Katharina, Franke, Annika, Manstein, Felix, Bolesani, Emiliano, Kempf, Henning, Liebscher, Simone, Schenke-Layland, Katja, Hegermann, Jan, Nolte, Lena, Meyer, Heiko, de la Roche, Jeanne, Thiemann, Stefan, Wahl-Schott, Christian, Martin, Ulrich, Zweigerdt, Robert
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group US 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192303/
https://ncbi.nlm.nih.gov/pubmed/33558697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-021-00815-9
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