Glycosylation limits forward trafficking of the tetraspan membrane protein PMP22

Peripheral myelin protein 22 (PMP22) folds and trafficks inefficiently, with only 20% of newly expressed protein trafficking to the cell surface. This behavior is exacerbated in many of the mutants associated with Charcot–Marie–Tooth disease, motivating further study. Here we characterized the role...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Marinko, Justin T., Wright, Madison T., Schlebach, Jonathan P., Clowes, Katherine R., Heintzman, Darren R., Plate, Lars, Sanders, Charles R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191293/
https://ncbi.nlm.nih.gov/pubmed/33933451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100719
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