Glycosylation limits forward trafficking of the tetraspan membrane protein PMP22

Peripheral myelin protein 22 (PMP22) folds and trafficks inefficiently, with only 20% of newly expressed protein trafficking to the cell surface. This behavior is exacerbated in many of the mutants associated with Charcot–Marie–Tooth disease, motivating further study. Here we characterized the role...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Marinko, Justin T., Wright, Madison T., Schlebach, Jonathan P., Clowes, Katherine R., Heintzman, Darren R., Plate, Lars, Sanders, Charles R.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191293/
https://ncbi.nlm.nih.gov/pubmed/33933451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100719
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