ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes

BACKGROUND: Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or poor prognosis, but the underlying mechanisms are largely unknown. The limonoid...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Cancer
Auteurs principaux: Yu, Fang, Gajendran, Babu, Wang, Ning, Sample, Klarke M., Liu, Wuling, Wang, Chunlin, Hu, Anling, Zacksenhaus, Eldad, Hao, Xiaojiang, Ben-David, Yaacov
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191108/
https://ncbi.nlm.nih.gov/pubmed/34107900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-08402-6
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