ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes

BACKGROUND: Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or poor prognosis, but the underlying mechanisms are largely unknown. The limonoid...

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Detaylı Bibliyografya
Yayımlandı:BMC Cancer
Asıl Yazarlar: Yu, Fang, Gajendran, Babu, Wang, Ning, Sample, Klarke M., Liu, Wuling, Wang, Chunlin, Hu, Anling, Zacksenhaus, Eldad, Hao, Xiaojiang, Ben-David, Yaacov
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191108/
https://ncbi.nlm.nih.gov/pubmed/34107900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-08402-6
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