A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3

The SIN3 repressor complex and the NAD-dependent deacetylase SIRT3 control cell growth, and development as well as malignant transformation. Even then, a little known about cross-talks between these two chromatin modifiers or whether their interaction explored therapeutically. Here we describe the i...

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Publicado no:Commun Biol
Main Authors: Gajendran, Babu, Varier, Krishnapriya M., Liu, Wuling, Wang, Chunlin, Sample, Klarke M., Zacksenhaus, Eldad, Juiwei, Cui, Huang, LieJun, Hao, XiaoJiang, Ben-David, Yaacov
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713351/
https://ncbi.nlm.nih.gov/pubmed/33273692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01458-3
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