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HIV Reverse Transcriptase Pre-Steady-State Kinetic Analysis of Chain Terminators and Translocation Inhibitors Reveals Interactions between Magnesium and Nucleotide 3′-OH
[Image: see text] Deoxythymidine triphosphate analogues with various 3′ substituents in the sugar ring (−OH (dTTP)), −H, −N(3), −NH(2), −F, −O–CH(3), no group (2′,3′-didehydro-2′,3′-dideoxythymidine triphosphate (d4TTP)), and those retaining the 3′-OH but with 4′ additions (4′-C-methyl, 4′-C-ethyl)...
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| Veröffentlicht in: | ACS Omega |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2021
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8190884/ https://ncbi.nlm.nih.gov/pubmed/34124485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.1c01742 |
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