Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations

Amyotrophic lateral sclerosis (ALS) is an adult-onset incurable motor neuron (MN) disease. The reasons for selective MN vulnerability in ALS are unknown. Axonal pathology is among the earliest signs of ALS. We searched for novel modulatory genes in human MN axon shortening affected by TARDBP mutatio...

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Publicado no:Stem Cell Reports
Main Authors: Mitsuzawa, Shio, Suzuki, Naoki, Akiyama, Tetsuya, Ishikawa, Mitsuru, Sone, Takefumi, Kawada, Jiro, Funayama, Ryo, Shirota, Matsuyuki, Mitsuhashi, Hiroaki, Morimoto, Satoru, Ikeda, Kensuke, Shijo, Tomomi, Ohno, Akiyuki, Nakamura, Naoko, Ono, Hiroya, Ono, Risako, Osana, Shion, Nakagawa, Tadashi, Nishiyama, Ayumi, Izumi, Rumiko, Kaneda, Shohei, Ikeuchi, Yoshiho, Nakayama, Keiko, Fujii, Teruo, Warita, Hitoshi, Okano, Hideyuki, Aoki, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190591/
https://ncbi.nlm.nih.gov/pubmed/34048688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.04.021
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