Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

CAR T cell therapy remains ineffective in solid tumors, due largely to poor infiltration and T cell suppression at the tumor site. T regulatory (T(reg)) cells suppress the immune response via inhibitory factors such as transforming growth factor–β (TGF-β). T(reg) cells expressing the C-C chemokine r...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Sci Adv
المؤلفون الرئيسيون: Cadilha, Bruno L., Benmebarek, Mohamed-Reda, Dorman, Klara, Oner, Arman, Lorenzini, Theo, Obeck, Hannah, Vänttinen, Mira, Di Pilato, Mauro, Pruessmann, Jasper N., Stoiber, Stefan, Huynh, Duc, Märkl, Florian, Seifert, Matthias, Manske, Katrin, Suarez-Gosalvez, Javier, Zeng, Yi, Lesch, Stefanie, Karches, Clara H., Heise, Constanze, Gottschlich, Adrian, Thomas, Moritz, Marr, Carsten, Zhang, Jin, Pandey, Dharmendra, Feuchtinger, Tobias, Subklewe, Marion, Mempel, Thorsten R., Endres, Stefan, Kobold, Sebastian
التنسيق: Artigo
اللغة:Inglês
منشور في: American Association for the Advancement of Science 2021
الموضوعات:
Research Articles
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189699/
https://ncbi.nlm.nih.gov/pubmed/34108220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abi5781
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