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Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors
CAR T cell therapy remains ineffective in solid tumors, due largely to poor infiltration and T cell suppression at the tumor site. T regulatory (T(reg)) cells suppress the immune response via inhibitory factors such as transforming growth factor–β (TGF-β). T(reg) cells expressing the C-C chemokine r...
Zapisane w:
| Wydane w: | Sci Adv |
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| Główni autorzy: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Association for the Advancement of Science
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8189699/ https://ncbi.nlm.nih.gov/pubmed/34108220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abi5781 |
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