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The oxidation and hypoglycaemic effect of sorafenib in streptozotocin-induced diabetic rats
BACKGROUND: Diabetes reduces the activity of CYP3A4 and may increase the exposure for the drugs metabolized by the isoenzyme. Sorafenib is a multi-targeted tyrosine kinase inhibitor (TKI), used for the treatment of advanced renal cell carcinoma, hepatocellular carcinoma and radioactive iodine resist...
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| Publicado no: | Pharmacol Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8187206/ https://ncbi.nlm.nih.gov/pubmed/32016844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43440-019-00021-0 |
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