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The oxidation and hypoglycaemic effect of sorafenib in streptozotocin-induced diabetic rats

BACKGROUND: Diabetes reduces the activity of CYP3A4 and may increase the exposure for the drugs metabolized by the isoenzyme. Sorafenib is a multi-targeted tyrosine kinase inhibitor (TKI), used for the treatment of advanced renal cell carcinoma, hepatocellular carcinoma and radioactive iodine resist...

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Detalles Bibliográficos
Publicado en:Pharmacol Rep
Main Authors: Karbownik, Agnieszka, Stachowiak, Anna, Urjasz, Hanna, Sobańska, Katarzyna, Szczecińska, Agnieszka, Grabowski, Tomasz, Stanisławiak-Rudowicz, Joanna, Wolc, Anna, Grześkowiak, Edmund, Szałek, Edyta
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187206/
https://ncbi.nlm.nih.gov/pubmed/32016844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43440-019-00021-0
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