Synthesis and biological evaluation of thiazolidinedione derivatives with high ligand efficiency to P. aeruginosa PhzS

The thiazolidinone ring is found in compounds that have widespan biology activity and there is mechanism-based evidence that compounds bearing this moiety inhibit P. aeruginosa PhzS (PaPzhS), a key enzyme in the biosynthesis of the virulence factor named pyocyanin. Ten novel thiazolidinone derivativ...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Main Authors: Froes, Thamires Quadros, Chaves, Bianca Trindade, Mendes, Marina Sena, Ximenes, Rafael Matos, da Silva, Ivanildo Mangueira, da Silva, Priscila Brandão Gomes, de Albuquerque, Julianna Ferreira Cavalcanti, Castilho, Marcelo Santos
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2021
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186431/
https://ncbi.nlm.nih.gov/pubmed/34080514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1931165
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