Synthesis and biological evaluation of thiazolidinedione derivatives with high ligand efficiency to P. aeruginosa PhzS

The thiazolidinone ring is found in compounds that have widespan biology activity and there is mechanism-based evidence that compounds bearing this moiety inhibit P. aeruginosa PhzS (PaPzhS), a key enzyme in the biosynthesis of the virulence factor named pyocyanin. Ten novel thiazolidinone derivativ...

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Dades bibliogràfiques
Publicat a:J Enzyme Inhib Med Chem
Autors principals: Froes, Thamires Quadros, Chaves, Bianca Trindade, Mendes, Marina Sena, Ximenes, Rafael Matos, da Silva, Ivanildo Mangueira, da Silva, Priscila Brandão Gomes, de Albuquerque, Julianna Ferreira Cavalcanti, Castilho, Marcelo Santos
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186431/
https://ncbi.nlm.nih.gov/pubmed/34080514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1931165
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