A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism

BACKGROUND: Hypoxia signaling, especially the hypoxia inducible factor (HIF) pathway, is a major player in clear cell renal cell carcinoma (ccRCC), which is characterized by disorders in lipid and glycogen metabolism. However, the interaction between hypoxia and lipid metabolism in ccRCC progression...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Liu, Ren, Feng, Yuanfa, Deng, Yulin, Zou, Zhihao, Ye, Jianheng, Cai, Zhiduan, Zhu, Xuejin, Liang, Yingke, Lu, Jianming, Zhang, Hui, Luo, Yong, Han, Zhaodong, Zhuo, Yangjia, Xie, Qingling, Hon, Chi Tin, Liang, Yuxiang, Wu, Chin-Lee, Zhong, Weide
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185942/
https://ncbi.nlm.nih.gov/pubmed/34098990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01996-6
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