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Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically-Labelled α-Synuclein with Site-specific Tyrosine Phosphorylation
Post-translational modifications (PTMs) can affect the normal function and pathology of α-synuclein (αS), an amyloid fibril forming protein linked to Parkinson’s disease. Phosphorylation of αS Tyr39 has recently been found to display a dose-dependent effect on fibril formation kinetics and to alter...
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| Publicado no: | Chembiochem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8185324/ https://ncbi.nlm.nih.gov/pubmed/33274519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000742 |
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