RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

Recent data suggest that therapy-resistant quiescent cancer stem cells (qCSCs) are the source of relapse in colon cancer. Here, using colon cancer patient-derived organoids and xenografts, we identify rare long-term label-retaining qCSCs that can re-enter the cell cycle to generate new tumors. RNA s...

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Bibliografske podrobnosti
izdano v:iScience
Main Authors: Regan, Joseph L., Schumacher, Dirk, Staudte, Stephanie, Steffen, Andreas, Lesche, Ralf, Toedling, Joern, Jourdan, Thibaud, Haybaeck, Johannes, Mumberg, Dominik, Henderson, David, Győrffy, Balázs, Regenbrecht, Christian R.A., Keilholz, Ulrich, Schäfer, Reinhold, Lange, Martin
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185225/
https://ncbi.nlm.nih.gov/pubmed/34142064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102618
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