RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

Recent data suggest that therapy-resistant quiescent cancer stem cells (qCSCs) are the source of relapse in colon cancer. Here, using colon cancer patient-derived organoids and xenografts, we identify rare long-term label-retaining qCSCs that can re-enter the cell cycle to generate new tumors. RNA s...

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Détails bibliographiques
Publié dans:iScience
Auteurs principaux: Regan, Joseph L., Schumacher, Dirk, Staudte, Stephanie, Steffen, Andreas, Lesche, Ralf, Toedling, Joern, Jourdan, Thibaud, Haybaeck, Johannes, Mumberg, Dominik, Henderson, David, Győrffy, Balázs, Regenbrecht, Christian R.A., Keilholz, Ulrich, Schäfer, Reinhold, Lange, Martin
Format: Artigo
Langue:Inglês
Publié: Elsevier 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185225/
https://ncbi.nlm.nih.gov/pubmed/34142064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102618
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