Sam68 promotes hepatic gluconeogenesis via CRTC2

Hepatic gluconeogenesis is essential for glucose homeostasis and also a therapeutic target for type 2 diabetes, but its mechanism is incompletely understood. Here, we report that Sam68, an RNA-binding adaptor protein and Src kinase substrate, is a novel regulator of hepatic gluconeogenesis. Both glo...

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Pubblicato in:Nat Commun
Autori principali: Qiao, Aijun, Zhou, Junlan, Xu, Shiyue, Ma, Wenxia, Boriboun, Chan, Kim, Teayoun, Yan, Baolong, Deng, Jianxin, Yang, Liu, Zhang, Eric, Song, Yuhua, Ma, Yongchao C., Richard, Stephane, Zhang, Chunxiang, Qiu, Hongyu, Habegger, Kirk M., Zhang, Jianyi, Qin, Gangjian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185084/
https://ncbi.nlm.nih.gov/pubmed/34099657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23624-9
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