A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids

Excess glucocorticoids (GCs) with either endogenous or exogenous origins deteriorate skin barrier function. GCs bind to mineralocorticoid and GC receptors (MRs and GRs) in normal human epidermal keratinocytes (NHEKs). Inappropriate MR activation by GCs mediates various GC-induced cutaneous adverse e...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Lee, Hanil, Choi, Eun-Jeong, Kim, Eun Jung, Son, Eui Dong, Kim, Hyoung-June, Park, Won-Seok, Kang, Young-Gyu, Shin, Kyong-Oh, Park, Kyungho, Kim, Jin-Chul, Kim, Su-Nam, Choi, Eung Ho
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184959/
https://ncbi.nlm.nih.gov/pubmed/34099793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91450-6
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