A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids

Excess glucocorticoids (GCs) with either endogenous or exogenous origins deteriorate skin barrier function. GCs bind to mineralocorticoid and GC receptors (MRs and GRs) in normal human epidermal keratinocytes (NHEKs). Inappropriate MR activation by GCs mediates various GC-induced cutaneous adverse e...

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書誌詳細
出版年:Sci Rep
主要な著者: Lee, Hanil, Choi, Eun-Jeong, Kim, Eun Jung, Son, Eui Dong, Kim, Hyoung-June, Park, Won-Seok, Kang, Young-Gyu, Shin, Kyong-Oh, Park, Kyungho, Kim, Jin-Chul, Kim, Su-Nam, Choi, Eung Ho
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184959/
https://ncbi.nlm.nih.gov/pubmed/34099793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91450-6
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