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Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases with overlapping clinical features and the pathological hallmark of cytoplasmic deposits of misfolded proteins. The most frequent cause of familial forms of these diseases is a hexanucleotide repeat expansio...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8184751/ https://ncbi.nlm.nih.gov/pubmed/34099711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23691-y |
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