Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials

BACKGROUND: Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) exerts corrective effects on the dysregulated migration characteristics of neutrophils isolated from patients with chronic obstructive pulmonary disease (COPD). OBJECTIVE: To develop novel, induced sputum endpoints to demonstrate changes...

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Pubblicato in:Int J Chron Obstruct Pulmon Dis
Autori principali: Begg, Malcolm, Hamblin, J Nicole, Jarvis, Emily, Bradley, Glyn, Mark, Stephen, Michalovich, David, Lennon, Mark, Wajdner, Hannah E, Amour, Augustin, Wilson, Robert, Saunders, Ken, Tanaka, Rikako, Arai, Saki, Tang, Teresa, Van Holsbeke, Cedric, De Backer, Jan, Vos, Wim, Titlestad, Ingrid L, FitzGerald, J Mark, Killian, Kieran, Bourbeau, Jean, Poirier, Claude, Maltais, François, Cahn, Anthony, Hessel, Edith M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2021
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184158/
https://ncbi.nlm.nih.gov/pubmed/34113094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S309303
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